Childhood nephrotic syndrome has a relatively favorable long-term prognosis. The aim of study is to describe the therapeutic measures used for the management of Nephrotic syndrome in pediatrics. A Prospective, non- intervention observational study was conducted at Pediatric Department, SAT Hospital, Govt.Medical College, Thiruvananthapuram. A total of 87 patients satisfying these criteria were enrolled during the visit to in-patient and out-patient department during July 2008 to November 2008. Of the 87 patients, the prevalence of NS was found to be higher in males 62.1%. 27.3% of the patients had 3 months of steroid treatment followed by 6 months 15.6%. Majority of the patients had complication of respiratory tract infection 18.3%. 73.6% patients experienced moon face as the side effect of steroid. 83.9 % of patients are compliant with medicines, 74.9% were compliant with food and 77% compliant with activities. The present study can be considered as a pilot study and further studies regarding its efficacy of drugs used and influence of specific therapy in decreasing relapse frequency can be done
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